Insight into the pediatric and adult dichotomy of COVID-19: Age-related differences in the immune response to SARS-CoV-2 infection.
Identifieur interne : 000498 ( Main/Exploration ); précédent : 000497; suivant : 000499Insight into the pediatric and adult dichotomy of COVID-19: Age-related differences in the immune response to SARS-CoV-2 infection.
Auteurs : Allison Fialkowski [États-Unis] ; Yael Gernez [États-Unis] ; Puneeta Arya [États-Unis] ; Katja G. Weinacht [États-Unis] ; T Bernard Kinane [États-Unis] ; Lael M. Yonker [États-Unis]Source :
- Pediatric pulmonology [ 1099-0496 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- immunology : Aging, COVID-19, Systemic Inflammatory Response Syndrome.
- physiology : SARS-CoV-2.
- Adaptive Immunity, Adult, Child, Humans, Immunity, Innate, Virus Internalization.
Abstract
The difference in morbidity and mortality between adult and pediatric coronavirus disease 2019 infections is dramatic. Understanding pediatric-specific acute and delayed immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for the development of vaccination strategies, immune-targeted therapies, and treatment and prevention of multisystem inflammatory syndrome in children. The goal of this review is to highlight research developments in the understanding of the immune responses to SARS-CoV-2 infections, with a specific focus on age-related immune responses.
DOI: 10.1002/ppul.24981
PubMed: 32710693
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Yonker</name><affiliation wicri:level="2"><nlm:affiliation>Harvard Medical School, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard Medical School, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Division of Pulmonary, Massachusetts General Hospital for Children, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Pulmonary, Massachusetts General Hospital for Children, Boston</wicri:cityArea></affiliation></author></analytic><series><title level="j">Pediatric pulmonology</title><idno type="eISSN">1099-0496</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptive Immunity (MeSH)</term><term>Adult (MeSH)</term><term>Aging (immunology)</term><term>COVID-19 (immunology)</term><term>Child (MeSH)</term><term>Humans (MeSH)</term><term>Immunity, Innate (MeSH)</term><term>SARS-CoV-2 (physiology)</term><term>Systemic Inflammatory Response Syndrome (immunology)</term><term>Virus Internalization (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Enfant (MeSH)</term><term>Humains (MeSH)</term><term>Immunité acquise (MeSH)</term><term>Immunité innée (MeSH)</term><term>Pénétration virale (MeSH)</term><term>Syndrome de réponse inflammatoire généralisée (immunologie)</term><term>Vieillissement (immunologie)</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Syndrome de réponse inflammatoire généralisée</term><term>Vieillissement</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Aging</term><term>COVID-19</term><term>Systemic Inflammatory Response Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS-CoV-2</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adaptive Immunity</term><term>Adult</term><term>Child</term><term>Humans</term><term>Immunity, Innate</term><term>Virus Internalization</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Enfant</term><term>Humains</term><term>Immunité acquise</term><term>Immunité innée</term><term>Pénétration virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The difference in morbidity and mortality between adult and pediatric coronavirus disease 2019 infections is dramatic. Understanding pediatric-specific acute and delayed immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for the development of vaccination strategies, immune-targeted therapies, and treatment and prevention of multisystem inflammatory syndrome in children. The goal of this review is to highlight research developments in the understanding of the immune responses to SARS-CoV-2 infections, with a specific focus on age-related immune responses.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">32710693</PMID><DateCompleted><Year>2020</Year><Month>12</Month><Day>18</Day></DateCompleted><DateRevised><Year>2020</Year><Month>12</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1099-0496</ISSN><JournalIssue CitedMedium="Internet"><Volume>55</Volume><Issue>10</Issue><PubDate><Year>2020</Year><Month>10</Month></PubDate></JournalIssue><Title>Pediatric pulmonology</Title><ISOAbbreviation>Pediatr Pulmonol</ISOAbbreviation></Journal><ArticleTitle>Insight into the pediatric and adult dichotomy of COVID-19: Age-related differences in the immune response to SARS-CoV-2 infection.</ArticleTitle><Pagination><MedlinePgn>2556-2564</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/ppul.24981</ELocationID><Abstract><AbstractText>The difference in morbidity and mortality between adult and pediatric coronavirus disease 2019 infections is dramatic. Understanding pediatric-specific acute and delayed immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for the development of vaccination strategies, immune-targeted therapies, and treatment and prevention of multisystem inflammatory syndrome in children. The goal of this review is to highlight research developments in the understanding of the immune responses to SARS-CoV-2 infections, with a specific focus on age-related immune responses.</AbstractText><CopyrightInformation>© 2020 Wiley Periodicals LLC.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fialkowski</LastName><ForeName>Allison</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Harvard Medical School, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gernez</LastName><ForeName>Yael</ForeName><Initials>Y</Initials><Identifier Source="ORCID">0000-0001-6453-2901</Identifier><AffiliationInfo><Affiliation>Department of Pediatric Allergy and Immunology, Stanford University, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arya</LastName><ForeName>Puneeta</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Harvard Medical School, Boston, Massachusetts.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Cardiology, Massachusetts General Hospital for Children, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weinacht</LastName><ForeName>Katja G</ForeName><Initials>KG</Initials><AffiliationInfo><Affiliation>Department of Stem Cell Transplantation and Regenerative Medicine, Stanford University, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kinane</LastName><ForeName>T Bernard</ForeName><Initials>TB</Initials><Identifier Source="ORCID">0000-0002-5668-1066</Identifier><AffiliationInfo><Affiliation>Harvard Medical School, Boston, Massachusetts.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Pulmonary, Massachusetts General Hospital for Children, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yonker</LastName><ForeName>Lael M</ForeName><Initials>LM</Initials><Identifier Source="ORCID">0000-0003-1711-8227</Identifier><AffiliationInfo><Affiliation>Harvard Medical School, Boston, Massachusetts.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Pulmonary, Massachusetts General Hospital for Children, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Pediatr Pulmonol</MedlineTA><NlmUniqueID>8510590</NlmUniqueID><ISSNLinking>1099-0496</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000705967">pediatric multisystem inflammatory disease, COVID-19 related</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D056704" MajorTopicYN="N">Adaptive Immunity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000375" MajorTopicYN="N">Aging</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007113" MajorTopicYN="N">Immunity, Innate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="Y">SARS-CoV-2</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018746" MajorTopicYN="N">Systemic Inflammatory Response Syndrome</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053586" MajorTopicYN="N">Virus Internalization</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">SARS-CoV-2 infection</Keyword><Keyword MajorTopicYN="Y">age-related immune response</Keyword><Keyword MajorTopicYN="Y">childhood COVID-19</Keyword><Keyword MajorTopicYN="Y">pediatric COVID-19</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>06</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>07</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>12</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32710693</ArticleId><ArticleId IdType="doi">10.1002/ppul.24981</ArticleId></ArticleIdList><ReferenceList><Title>REFERENCES</Title><Reference><Citation>Oberfeld B, Achanta A, Carpenter K, et al. 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